Description

Montelukast 10 mg + Fexofenadine 120 mg Tablet

Montelukast 10 mg

Montelukast is a leukotriene antagonist. It binds with high affinity to the LTD4 receptor inhibiting bronchoconstriction. Crysteinyl. Leukotrienes (LTC4, LTD4, LTE4) are important pro inflammatory. Mediators in asthma and also they have been correlated with the physiology of asthma.

Indications

Prophylaxis and treatment of asthma. Aspirin Induced asthma.

Contraindications

Hypersensitivity.

Safety Profile

It should not be abruptly, substitute for inhaled or oral corticosteroids.

Adverse Effects

Churg- strauss syndrome, angioedema and skin reactions.

Drug Interactions

Phenytoin rifampin and carbamazepine, decrease the plasma concentration of montelukast.

Dosage

Adults 10 mg tab OD

Children : 6-14 years 5 mg od, 2-5 years 2 mg od.

Fexofenadine 120 mg

Selective H1 antagonist good GI absorption. Excretion mainly in bile, little in urine.

Indications

Allergic rhinitis, Allergic skin disorders.

Contraindications

Hypersensitivity.

Safety Profile

Prescribe to pregnant women only if potential benefit out weight the potential risk to foetus, lactation.

Adverse Effects

Fatigue, headache, drowsiness, dyspepsia, nausea.

Drug Interactions

Ketoconazole and erythromycin inhibit the metabolism and increase plasma concentration.

Dosage

120mg – 180mg once a day