Description

Montelukast 4 mg + Levocetirizine 2.5 mg Suspension

Montelukast 4mg

Montelukast is a leukotriene antagonist. It binds with high affinity to the LTD4 receptor inhibiting bronchoconstriction. Crysteinyl. Leukotrienes (LTC4, LTD4, LTE4) are important pro inflammatory. Mediators in asthma and also they have been correlated with the physiology of asthma.

Indications

Prophylaxis and treatment of asthma. Aspirin Induced asthma.

Contraindications

Hypersensitivity.

Safety Profile

It should not be abruptly, substitute for inhaled or oral corticosteroids.

Adverse Effects

Churg- strauss syndrome, angioedema and skin reactions.

Drug Interactions

Phenytoin rifampin and carbamazepine, decrease the plasma concentration of montelukast.

Dosage

Adults 10 mg tab OD

Children : 6-14 years 5 mg od, 2-5 years 2 mg od.

Levocetirizine 2.5mg

Levocetirizine diyar ochloride is a new generation non sedative long acting H1 receptor antagonist antihistamine with less side-effects compared with other antihistamines. It is a selective peripheral H1 receptor antagonist.

Indications

Seasonal allergic rhinitis, perennial allergic rhinitis, ocular symptom (such as redness, lacrimation and itching.) Chronic idiopathic urticaria, dermographism, atopic eczema and contact dermatitis, acute allergic reactions due to drugs.

Contraindications

Hypersensitivity to levocetirizine or to any piperazine derivative, patient  with severe renal impairment.

Safety Profile

Patient involving to drive/ operate machine, concurrent use with alcohol.

Adverse Effects

Headache, somnolence, dry mouth, fatigue, rhinitis, pharyngitis, asthenia, abdominal pain, migraine, GI disturbances, mild drowsiness.

Drug Interactions

The extent of absorption of other CNS depressants may have effects on the CNS.

Dosage

5mg. Oral.