Vitamin B complex refers to the family of B vitamins, which includes thiamine, riboflavin, niacin, folate, biotin and vitamins B5, B6 and B12. These vitamins serve many important roles throughout the body but are particularly important in supporting some essential liver functions — including detoxification of drugs and chemicals, and processing and metabolism of dietary proteins, fats and sugars.
B vitamin deficiencies occur in some people with advanced cirrhosis, which can result from various forms of hepatitis. People with alcoholic liver disease are particularly prone to B vitamin deficiencies. These deficiencies typically develop because of malnutrition, poor absorption of vitamins from the intestines and changes in blood circulation that result in increased loss of B vitamins through the kidneys.
It is a plant product obtained from Silybon marianum. It is an antthepatotoxix drug. It stimulates RNA polymerase A also, it is a strong antioxidant and inhibits prostaglandin synthesis. It also produces some changes in the membrane phospholipid so that certain toxins cannot enter the cells, thus increasing the phagocytic activity. Along with this, it enhances glutathione synthesis in the liver it gets concentrated in liver, when given orally. It undergoes enterohepatic circulation and is eliminated in bile.
Hepatitis A, chronic active hepatitis, fatty liver, carbon tetrachloride poisoning and mushroom poisoning. Supportive therapy in cirrhosis and alcoholic liver disease.
Hepatic encephalopathy, primary biliary cirrhosis, obstructive jaundice.
70-140 mg b.i.d..